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Cambridge Infinitus Research Centre



Bali K, Guffick C, McCoy R, Lu Z, Kaminski CF, Mela I, Owens RM and van Veen HW.  Biosensor for multimodal characterisation of an essential ABC transport for next-generation antibiotic research, ACS Applied Materials & Interfaces (2023) 10.1021/acsami.2c21556.  DOI

Stephens AD, Fernandez Villegas A, Chung CW, Vanderpoorten O, Pinotsi D, Mela I, Ward E, McCoy TM, Cubitt R, Routh AF, Kaminski CF and Kaminski Schierle GS α-Synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased lipid-associated fibril uptake into iPSC-derived neurons, Commun Biol. (2023) 6, 526.  DOI

Ward EN, McClelland RM, Lamb JR, Rubio-Sanchez R, Christensen CN, Mazumder B, Kapsiani S, Mascheroni L, Di Michele L, Kaminski Schierle GS and Kaminski CF.  Fast, multicolour optical sectioning over extended fields of view by combining interferometric SIM with machine learning, arXiv preprint (2023) arXiv:2311.00089v1. PDF


Bali K, Mohamed Z, Scheeder A, Pappa A-M, Daniel S, Kaminski CF, Owens RM and Mela A.  Nanoscale features of tunable bacterial outer membrane models revealed by correlative microscopy, ACS Langmuir (2022) 10.1021.  DOI

Chambers JE, Zubkov N, Kubankova M, Nixon-Abell J, Mela I, Abreu S, Schwiening M, Lavarda G, Lopez-Duarte I, Dickens JA, Torres T, Kaminski CF, Holt LJ, Avezov E, Huntington JA, St George-Hyslop P, Kuimova MK, Marchiniak SJ.  Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state, Science Advances (2022) 8, 14.  DOI  PDF

Christensen CN, Lu M, Ward EN, Lio P, Kaminski CF.  Spatio-temporal vision transformer for super-resolution microscopy, arXiv (2022) 2203.00030v1. PDF

Li W, Kaminski Schierle GS, Lei B, Liu Y and Kaminski CF.  Fluorescent nanoparticles for super-resolution imaging, Chem. Rev. (2022). DOI.

Ward EN, Hecker L, Christensen CN, Lamb JR, Lu M, Mascheroni L, Chung CW, Wang A, Rowlands CJ, Kaminski Schierle GS, Kaminski CF.  Machine learning assisted interferometric structured illumination microscopy for dynamic biological imaging, Nat Commun (2022) 13, 7836.  DOI


Bali K, Mohamed Z, Pappa A, Daniel S, Kaminski CF, Owens, RM, Mela I.  Correlative microscopy reveals the nanoscale morphology of E. coli-derived supported lipid bilayers, bioRxiv (2021) PPR:PPR415977.  DOI

Chung CW, Stephens AD, Ward E, Feng Y, Davis MJ, Kaminsk CF, Kaminski Schierle GS.  Label-free characterisation of amyloids and alpha-Synuclein polymorphs by exploiting their intrinsic fluorescence property, bioRxiv (2021) 10.1101/2021.11.30.470691.  DOI

Darvishi S, Tavakoli S, Kharaziha M, Girault HH, Kaminski CF, Mela I.  Advances in the sensing and treatment of wound biofilms, Angew. Chem. Int. Ed. (2021), 10.1002/anie.202112218.  DOI

Lu M, Mishra A, Boschetti C, Lin J, Liu Y, Huang H, Kaminski CF, Huang Z, Tunnacliffe A, Kaminski Schierle GS.  Sea cucumber-derived peptides alleviate oxidative stress in neuroblastoma cells and improve survival in C. elegans exposed to neurotoxic paraquat, Oxidative Medicine and Cellular Longevity (2021) 8842926.  DOI

Lu M, Ward E, van Tartwijk FW, Kaminski CF.  Advances in the study of organelle interactions and their role in neurodegenerative diseases enabled by super-resolution microscopy, Neurobiology of Disease (2021) 105475.  DOI

Mela I, Poudel C, Anaya M, Delport G, Frohna K, Macpherson S, Doherty TAS, Stranks SD, Kaminski CF.  Revealing nanomechanical domains and their transient behavior in mixed-halide perovskite films, Adv. Funct. Mater. (2021) 31, 2100293.  DOI

Meng B, Vallejo Ramirez PP, Scherer KM, Bruggeman E, Kenyon JC, Kaminski CF, Lever AM. EAP45 association with budding HIV-1: Kinetics and domain requirements, Traffic (2021) DOI. PMID: 34580994. 

Scherer KM, Mascheroni L, Carnell GW, Wunderlich LCS, Makarchuk S, Brockhoff M, Mela I, Fernandez-Villegas A, Barysevich M, Stewart H, Suau Sans M, George CL, Lamb JR, Kaminski-Schierle GS, Heeney JL, Kaminski CFThe SARS-CoV-2 nucleocapsid protein associates with the replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress, bioRxiv (2021) 2021.06.15.448497.  DOI


Chakraborty T, Chen B, Daetwyler S, Chang B-J, Vanderpoorten O, Sapoznik E, Kaminski CF, Knowles TPJ, Dean KM, Fiolka R.  Converting lateral scanning into axial focussing to speed up three-dimensional microscopy, Light Sci Appl (2020) 9, 165.  DOI

Christensen CN, Ward EN, Lio P, Kaminski CF.  ML-SIM: A deep neural network for reconstruction of structured illumination microscopy imagesarXiv (2020) 2003.11064.  PDF

Haddad S, Abanades Lazaro I, Fantham MJ, Mishra A, Silvestre-Albero J, Osterrieth JWM, Kaminski Schierle GS, Kaminski CF, Forgan R, Fairen-Jimenez D.  Design of a functionalized metal-organic framework system for enhanced targeted delivery to mitochondria, J. Am. Chem. Soc. (2020) IN PRESS. DOI  PDF

Lautenschläger J, Wagner-Valladolid S, Stephens AD, FernándezVillegas A, Hockings C, Mishra A, Manton JD, Fantham MJ, Lu M, Rees EJ, Kaminski CF, Kaminski Schierle GS.  Intra-mitochondrial proteostasis is directly coupled to alpha-synuclein and Amyloid β 1-42 pathology, bioRxiv (2020). DOI PDF

Lu M, Kaminski CFKaminski Schierle GSAdvanced fluorescence imaging of in situ protein aggregation, Phys. Biol. (2020) IN PRESS.  PDF

Lu M, van Tartwijk FW, Lin JQ, Nijenhuis W, Parutto P, Fantham M, Christensen CN, Avezov E, Holt CE, Tunnacliffe A, Holcman D, Kapitein L, Kaminski Schierle GS, Kaminski CF.  The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes, Science Advances (2020) 6 (51):eabc7209

Mela I, Kaminski CF.  Nano-vehicles give new lease of life to existing antimicrobials, Emerg Top Life Sci (2020) ETLS 20200153.  DOI

Mela I, Poudel C, Anaya M, Delport G, Frohna K, Macpherson S, Doherty TAS, Stranks SD, Kaminski CF.  Revealing nanomechanical domains and their transient behavior in mixed-halide perovskite films, arXiv (2020) 2011.08030.  PDF

Scherer KM, Manton JD, Soh TK, Mascheroni L, Connor V, Crump CM, Kaminski CF.  A flourescent reporter system enables spatiotemporal analysis of host cell modification during herpes simplex virus-1 replication, J. Biol. Chem. (2020) IN PRESS. DOI

Stephens AD, Lu M, Fernandez-Villegas A, Kaminski Schierle GS. Fast Purification of Recombinant Monomeric Amyloid-β from E. coli and Amyloid-β-mCherry Aggregates from Mammalian Cells, ACS Chemical Neuroscience (2020) 11 (20), 3204-3213.

Stephens AD, Matak-Vinkovic D, Fernandez-Villegas A, Kaminski Schierle GS.  Purification of Recombinant α-synuclein: A comparison of commonly used protocols, Biochemistry (2020) 59 (48), 4563-4572.  DOI

Stephens AD, Qaisrani MN, Ruggiero MT, Jones STE, Poli E, Bond AD, Woodhams PJ, Kleist EM, Grisanti LA, Gebauer R, Zeitler JA, Credgington D, Hassanali A, Kaminski Schierle GSIntrinsic fluorescence in non-aromatic peptide structures is induced by collective vibrations, charge reorganisation and short hydrogen bonds, as shown in a new glutamine-related structure, bioRxiv (2020).  DOI

Stephens AD, Zacharopoulou  M, Moons R, et al. Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity, Nat Commun (2020) 11, 2820. DOI

Wen Z, Wang L, Zhang X, Ma Y, Liu X, Kaminski CF, Yang Q.  Fast volumetric fluorescence imaging with mulitmode fibres, Optics Letters (2020) 45, 17, 4931-4934.  DOI

Wunderlich L, Ströhl F, Ströhl S, Vanderpoorten O, Mascheroni L, Kaminski CF.  Superresolving the kidney - a practical comparison of fluorescence nanoscopy of the glomerular filtration barrier, Anal. Bioanal. Chem. (2020).  DOI


Huang C, Wagner-Valladolid S, Stephens AD, Jung R, Poudel C, Sinnige T, Lechler MC, Schlörit N, Lu M, Laine RF, Michel CH, Vendruscolo M, Kaminski CF, Kaminski Schierle GS, David DC.  Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans, eLife (2019) 8, e43059.  DOI

Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF.  Fast fluorescence lifetime imaging reveals the aggregation processes of α-synuclein and polyglutamine in aging Caenorhabditis elegans, ACS Chem. Bio. (2019) 14, 7, 1628-1636.  DOI

Lautenschlaeger J, Wagner-Valladolid S, Stephens ADFernandez-Villegas A, Hockings C, Mishra A, Manton JD, Fantham MJ, Lu M, Rees EJ, Kaminski CF, Kaminski Schierle GSIntra-mitochondrial protein degradation allevaites alphasynuclein seeding and Abeta 42 aggregation, BioRxiv (2019) 561134.  DOI

Li W, Wu S, Xu X, Zhuang J, Zhang H, Zhang X, Hu C, Lei B, Kaminski CF, Liu Y.  Carbon dot-silica nanoparticle composites for ultralong lifetime phosphorescence imaging in tissue and cells at room temperature, Chem. Mater. (2019) 31, 23, 9887-9894.  DOI

Lu M, Banetta L, Young LJ, Smith EJ, Bates GP, Zaccone A, Kaminski Schierle GS, Tunnacliffe A, Kaminski CF.  Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly, J. Bio. Chem. (2019) 294 (1), 257-268.  PDF

Lu M, Williamson N, Mishra A, Michel CH, Kaminski CF, Tunnacliffe AKaminski Schierle GS. Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging, J. Biol. Chem. (2019), 294(5), pp.1478-1487. 

Manton JD, Ströhl F, Fiolka RP, Kaminski CF, Rees EJ.  Concepts for structured illumination microscopy with extended axial resolution through mirrored illumination, BioRxiv (2019) 828632.  DOI

Mela I, Vallejo-Ramirez PP, Makarchuk S, Christie G, Bailey D, Henderson RM, Sugiyama H, Endo M, Kaminski CFDNA origami nanostructures as a tool for the targeted destruction of bacteria, BioRxiv (2019) 837252.  DOI

Opstad IS, Ströhl F, Fantham MJ, Hockings C, Vanderpoorten O, van Tartwijk F, Lin JQ, Tinguely J-C, Dullo FT, Kaminski-Schierle GS, Ahluwalia BS, Kaminski CFA waveguide imaging platofrm for live-cell TIRF imaging of neurons over large fields of view, BioRxiv (2019).  DOI

Pang C, Li J, Tang M, Wang J, Mela I, Ströhl  F, Hecker L, Shen W, Liu Q, Liu X, Wang Y, Zhang H, Xu M, Zhang X, Liu X, Yang Q, Kaminski CFOn-chip super-resolution imaging with fluorescent polymer films, Adv. Funct. Mater. (2019) 29, 1900126. DOI

Poudel C, Kaminski CF.  Supercontinuum radiation in fluorescence microscopy and biomedical imaging applications, Journal of the Optical Society of America B (2019) 36 (2), A139-A153.  DOI

Ramirez PPV, Zammit J, Vanderpoorten O, Riche F, Blé FX, Zhou XH, Spiridon B, Valentine C, Spasov SE, Oluwasanya PW, Goodfellow G, Fantham MJ, Siddiqui O, Alimagham F, Robbins M, Stretton A, Simatos D, Hadeler O, Rees EJ, Ströhl F, Laine RF, Kaminski CFOptiJ: Open-source optical projection tomography of large organ samples, Scientific Reports (2019) 9, 15693DOI

Shigeoka T, Koppers M, Wong HHW, Lin JQ, Cagnetta R, Dwivedy A, de Freitas Nascimento J, van Tartwijk FW, Ströhl F, Cioni J-M, Schaeffer J, Carrington M, Kaminski CF, Jung H, Harris WA, Holt CE.  On-site ribosome remodeling by locally synthesized ribosomal proteins in axons, Cell Reports (2019) 29 (11), 3605-3619.  DOI

Stephens AD, Lu M, Kaminski Schierle GS. Isolation and Imaging of His-and RFP-tagged Amyloid-like Proteins from Caenorhabditis elegans by TEM and SIM, Bio-protocol (2019) 9 (21): e3408.

Ströhl  F, Kaminski CF.  A concept for single-shot volumetric fluorescence imaging via orthogonally polarized excitation lattices, Scientific Reports (2019) 9 (1), 6425.  DOI

Ströhl F, Opstad IS, Tinguely JC, Dullo FT, Kaminski CF, Ahluwalia BS.  Label-free nanoscopy enabled by coherent imaging with photonic waveguides, Proc. SPIE 11076, Advances in Microscopic Imaging II (2019) 11776Z.  PDF

Ströhl F, Opstad IS, Tinguely JC, Dullo FT, Mela I, Osterrieth JWM, Ahluwalia BS, Kaminski CFA super-condenser for labelfree nanoscopy, arXIv (2019) 1905.02401.  PDF

Ströhl F, Opstad IS, Tinguely JC, Dullo FT, Mela I, Osterrieth JWM, Ahluwalia BS, Kaminski CF.  Super-condenser enables labelfree nanoscopy, Optics Express (2019) 27 (18), 25280-25292.  PDF


Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF.  Fast fluorescence lifetime imaging reveals the maturation process of α-synuclein aggregates in ageing Caenorhabditis elegansbioRxiv (2018) 414714.  DOI

Laine RF, Goodfellow G, Young LJ, Travers J, Carroll D, Dibben O, Bright H, Kaminski CF.  MiLeSIM: combining super-resolution and machine learning permits high-throughput virus structure analysis, bioRxiv (2018) 266551.  DOI

Manton JD, Ströhl F, Fiolka R, Kaminski CF, Rees EJ.  Structured illumination microscopy with extended axial resolution through mirrored illumination, arXiv (2018) 1810.04590.  PDF

Moghadam PZ, Islamoglu T, Goswami S, Exley J, Fantham M, Kaminski CF, Snurr RQ, Farha OK, Fairen-Jimenez D. Computer-aided discovery of a metal-organic framework with superior oxygen uptake, Nature Communications (2018), 9 (1), 1378.  DOI

Rowlands CJ, Ströhl F, Ramirez PPV, Scherer KM, Kaminski CF.  Flat-field super-resolution localization microscopy with a low-cost refractive beam-shaping element, Scientific Reports (2018) 8 (1), 5630.  DOI

Russell CT, Rees EJ, Kaminski CF.  Homographically generated light sheets for the microscopy of large specimens, Optics Letters (2018) 43 (4), 663-666.  DOI

Shimanovich U, Pinotski D, Shimanovich K, Yu N, Bolisetty S, Adamcik J, Mezzenga R, Charmet J, Vollrath F, Gazit E, Dobson CM, Kaminski Schierle GS, Holland C, Kaminski CF, Knowles TPJ. Biophotonics of native silk fibrils, Macromol. Biosci. (2018) 18 (4) , 1700295.  DOI

Stephens, AD, Nespovitaya N, Zacharopoulou M, Kaminski CF, Phillips JJ, Kaminski Schierle GS.  Different structural conformers of monomeric α-synuclein identified after lyophilizing and freezing, Anal. Chem. (2018) 90 (11), 6975-6983.  DOI


Curry N, Ghézali G, Kaminski Schierle GS, Rouach N, Kaminski CFCorrelative STED and atomic force micrscopy on live astrocytes reveals plasticity of cytoskeletal structure and membrane physical properites during polarized migration, Front. Cell. Neurosci. (2017), 11, 140. DOI

Guttenplan APM, Young LJ, Matak-Vinkovic D, Kaminski CF, Knowles TPJ, Itzhaki L.  Nanoscale click-reactive scaffolds from peptide self-assembly, Journal of Nanobiotechnology (2017), 15 (1), 70.  DOI

Ströhl F, Wong HHW, Holt CE, Kaminski CF.  Total internal reflection fluorescence anisotropy imaging microscopy: setup, calibration, and data processing for protein polymerization measurements in living cells, Methods Appl. Fluoresc. (2017), 6 (1), 014004.  PDF

Teplensky MH, Fantham M, Li P, Wang TC, Mehta JP, Young LJ, Moghadam PZ, Hupp JT, Farha OK, Kaminski CF, Fairen-Jimenez D. Temperature treatment of highly porous zirconium-containing metal-organics frameworks extends drug delivery release, J. Am. Chem. Soc. (2017), 139 (22), 7522-7532.  DOI

Young LJ, Kaminski Schierle GS, Kaminski CF, Imaging Aβ (1-42) fibril elongation reveals strongly polarised growth and growth incompetent statesPhys. Chem. Chem. Phys. (2017), 19, 27987-27996.  DOI


Laine RF, Kaminski Schierle GS, van de Linde S, Kaminski CFFrom single-molecule spectroscopy to super-resolution imaging of the neuron: a review, Methods Appl. Fluoresc. (2016), 4: 022004. DOI 

Kaminski CF, Kaminski Schierle GSProbing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease, Neurophotonics (2016), 3(4): 041807. DOI 

Pinotsi D, Michel CH, Buell AK, Laine RF, Mahou P, Dobson CM, Kaminski CF, Kaminski Schierle GSNanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons, Proc. Natl. Acad. Sci. USA (2016), 113: 3815. DOI 


Lu M, Williamson N, Boschetti C, Ellis T, Yoshima T, Tunnacliffe A. Expression-level dependent perturbation of cell proteostasis and nuclear morphology by aggregation-prone polyglutamine proteins, Biotechnol. Bioeng. (2015), 112: 1883. DOI 

Lu M, Boschetti C, Tunnacliffe A. Long term aggresome accumulation leads to DNA damage, p53-dependent cell cycle arrest, and steric interference in mytosis, J. Biol. Chem. (2015), 290: 27986. DOI

Murakami T, Qamar S, Lin JQ, Kaminski Schierle GS, Rees E, Miyashita A,  Costa AR, Dodd RB, Chan FTS, Michel CH,  Kronenberg-Versteeg D, Li Y, Yang S-P,  Wakutani Y, Meadows W, Ferry RR, Dong L, Tartaglia GG, Favrin G,  Lin W-L,  Dickson DW,  Zhen M, Ron D, Schmitt-Ulms G, Fraser PE, Shneider NA, Holt C, Vendruscolo M, Kaminski CF, George-Hyslop P.St. ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function, Neuron (2015), 88(4): 687-690. DOI 


Fritschi SK, Langer F, Kaeser SA, Maia LF, Portelius E, Pinotsi D, Kaminski CF, Winkler DT, Maetzler W, Keyvani K, Spitzer P, Wiltfang J, Kaminski Schierle GS, Zetterberg H, Staufenbiel M, Jucker M. Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid, Brain (2014), 137(11): 2909-2915. DOI